Human defensin-inspired discovery of peptidomimetic antibiotics

作者：Gan Luo, Jue Zhang, Hanbin Wang, Yaqi Sun, Baoli Cheng, Zhipeng Xu, Yan Zhang, Hui Li, Wuyuan Lu, Elizabeta Nemeth, Tomas Ganz, Xiangming Fang · 发表于：Proceedings of the National Academy of Sciences · 年份：2022 · DOI：10.1073/pnas.2117283119 · 被引用次数：38 · 研究领域：Antimicrobial Peptides and Activities、Biochemical and Structural Characterization、Chemical Synthesis and Analysis

SignificanceWe report the development of peptidomimetic antibiotics derived from a natural antimicrobial peptide, human α-defensin 5. By engaging multiple bacterial targets, the lead compound is efficacious in vitro and in vivo against bacteria with highly inducible antibiotic resistance, promising a useful therapeutic agent for the treatment of infections caused by antibiotic-resistant bacteria.