Electrochemically mediated three-component synthesis of isothioureas using thiols as sulfur source

作者：Mu‐Xue He, Ping‐Fu Zhong, Hanfu Liu, Chuhong Ou, Ying‐Ming Pan, Haitao Tang · 发表于：Green Synthesis and Catalysis · 年份：2022 · DOI：10.1016/j.gresc.2022.03.002 · 被引用次数：37 · 研究领域：Sulfur-Based Synthesis Techniques、Multicomponent Synthesis of Heterocycles、Radical Photochemical Reactions

The simultaneous binding/dissociation of multiple bonds in a one-pot manner by multicomponent reactions provide an important approach for developing novel and sustainable pathway in the drug discovery process. Herein we develop an electrocatalytic three-component reaction to construct multifunctional and valuable isothiourea compounds, which uses thiols, isocyanides and amines as substrates. Compared with the previous work, the organic electrosynthesis technique can avoid the requirement of heavy metal catalysts and stoichiometric oxidants. In addition, using thiol as a substrate to participate in the three-component reaction broadens the source of sulfur, which can also construct more abundant isothiourea derivatives.