Drosophila Model for Studying Gut Microbiota in Behaviors and Neurodegenerative Diseases

作者：Meng-Hsuan Chiang, Shuk-Man Ho, Hui-Yu Wu, Yu-Chun Lin, Wan-Hua Tsai, Tony Wu, Chih‐Ho Lai, Chia‐Lin Wu · 发表于：Biomedicines · 年份：2022 · DOI：10.3390/biomedicines10030596 · 被引用次数：37 · 研究领域：Insect symbiosis and bacterial influences、Mosquito-borne diseases and control、Neurobiology and Insect Physiology Research

Mounting evidence indicates that the gut microbiota is linked to several physiological processes and disease development in mammals; however, the underlying mechanisms remained unexplored mostly due to the complexity of the mammalian gut microbiome. The fruit fly, Drosophila melanogaster, is a valuable animal model for studying host-gut microbiota interactions in translational aspects. The availability of powerful genetic tools and resources in Drosophila allowed the scientists to unravel the mechanisms by which the gut microbes affect fitness, health, and behavior of their hosts. Drosophila models have been extensively used not only to study animal behaviors (i.e., courtship, aggression, sleep, and learning & memory), but also some human related neurodegenerative diseases (i.e., Alzheimer’s disease and Parkinson’s disease) in the past. This review comprehensively summarizes the current understanding of the gut microbiota of Drosophila and its impact on fly behavior, physiology, and neurodegenerative diseases.