Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications

作者：Wen‐Chin Ko, Su‐Jane Wang, Chien‐Yu Hsiao, Chen‐Ting Hung, Yu-Jou Hsu, Der‐Chen Chang, Chi‐Feng Hung · 发表于：Molecules · 年份：2022 · DOI：10.3390/molecules27051551 · 被引用次数：112 · 研究领域：Nanoparticles: synthesis and applications、Nanoparticle-Based Drug Delivery、Advanced Nanomaterials in Catalysis

Gold has always been regarded as a symbol of nobility, and its shiny golden appearance has always attracted the attention of many people. Gold has good ductility, molecular recognition properties, and good biocompatibility. At present, gold is being used in many fields. When gold particles are as small as several nanometers, their physical and chemical properties vary with their size in nanometers. The surface area of a nano-sized gold surface has a special effect. Therefore, gold nanoparticles can, directly and indirectly, give rise to different biological activities. For example, if the surface of the gold is sulfided. Various substances have a strong chemical reactivity and are easy to combine with sulfhydryl groups; hence, nanogold is often used in biomedical testing, disease diagnosis, and gene detection. Nanogold is easy to bind to proteins, such as antibodies, enzymes, or cytokines. In fact, scientists use nanogold to bind special antibodies, as a tool for targeting cancer cells. Gold nanoparticles are also directly cytotoxic to cancer cells. For diseases caused by inflammation and oxidative damage, gold nanoparticles also have antioxidant and anti-inflammatory effects. Based on these unique properties, gold nanoparticles have become the most widely studied metal nanomaterials. Many recent studies have further demonstrated that gold nanoparticles are beneficial for humans, due to their functional pharmacological properties in a variety of diseases. The content of this ...