Bioceramic-based scaffolds with antibacterial function for bone tissue engineering: A review

作者：Chaoqian Zhao, Weiye Liu, Min Zhu, Chengtie Wu, Yufang Zhu · 发表于：Bioactive Materials · 年份：2022 · DOI：10.1016/j.bioactmat.2022.02.010 · 被引用次数：180 · 研究领域：Bone Tissue Engineering Materials、Graphene and Nanomaterials Applications、Nanoplatforms for cancer theranostics

Bone defects caused by trauma, tumor, congenital abnormality and osteoarthritis, etc. have been substantially impacted the lives and health of human. Artificial bone implants, like bioceramic-based scaffolds, provide significant benefits over biological counterparts and are critical for bone repair and regeneration. However, it is highly probable that bacterial infections occur in the surgical procedures or on bioceramic-based scaffolds. Therefore, it is of great significance to obtain bioceramic-based scaffolds with integrative antibacterial and osteogenic functions for treating bone implant-associated infection and promoting bone repair. To fight against infection problems, bioceramic-based scaffolds with various antibacterial strategies are developed for bone repair and regeneration and also have made great progresses. This review summarizes recent progresses in bioceramic-based scaffolds with antibacterial function, which include drug-induced, ion-mediated, physical-activated and their combined antibacterial strategies according to specific antibacterial mechanism. Finally, the challenges and opportunities of antibacterial bioceramic-based scaffolds are discussed.