Enhanced photodynamic therapy/photothermo therapy for nasopharyngeal carcinoma via a tumour microenvironment-responsive self-oxygenated drug delivery system

作者：Nan Wu, Yaqin Tu, Guorun Fan, Jiahui Ding, Jun Luo, Wei Wang, Chong Zhang, Caiyan Yuan, Handan Zhang, Pei Chen, Songwei Tan, Hongjun Xiao · 发表于：Asian Journal of Pharmaceutical Sciences · 年份：2022 · DOI：10.1016/j.ajps.2022.01.002 · 被引用次数：36 · 研究领域：Nanoplatforms for cancer theranostics、Photodynamic Therapy Research Studies、Cancer, Hypoxia, and Metabolism

The hypoxic nature of tumours limits the efficiency of oxygen-dependent photodynamic therapy (PDT). Hence, in this study, indocyanine green (ICG)-loaded lipid-coated zinc peroxide (ZnO2) nanoparticles (ZnO2@Lip-ICG) was constructed to realize tumour microenvironment (TME)-responsive self-oxygen supply. Near infrared light irradiation (808 nm), the lipid outer layer of ICG acquires sufficient energy to produce heat, thereby elevating the localised temperature, which results in accelerated ZnO2 release and apoptosis of tumour cells. The ZnO2 rapidly generates O2 in the TME (pH 6.5), which alleviates tumour hypoxia and then enhances the PDT effect of ICG. These results demonstrate that ZnO2@Lip-ICG NPs display good oxygen self-supported properties and outstanding PDT/PTT characteristics, and thus, achieve good tumour proliferation suppression.