Epidemiology and biology of early onset colorectal cancer

作者：Anand Venugopal, John M. Carethers · 发表于：PubMed · 年份：2021 · DOI：10.17179/excli2021-4456 · 被引用次数：78 · 研究领域：Colorectal Cancer Screening and Detection、Genetic factors in colorectal cancer、Gastric Cancer Management and Outcomes

somatic mutation, compared to loCRC. Other findings include LINE-1 hypomethylation, absence of microsatellite instability (MSI-H), presence of chromosomal instability (CIN) or microsatellite and chromosomal stability (MACS). These studies are only now emerging and have not yet identified a specific molecular signature defining eoCRC. Further research evaluating genetic and molecular differences as well as environmental triggers for eoCRCs should provide a clearer understanding to inform targeted screening for pre-symptomatic at-risk younger individuals.