An asymmetric three-component reaction of a diazo compound with an alcohol and a seven-membered imine

作者：Xiongda Xie, Ming Bao, Ke-Wei Chen, Xinfang Xu, Wenhao Hu · 发表于：Organic Chemistry Frontiers · 年份：2022 · DOI：10.1039/d2qo00076h · 被引用次数：9 · 研究领域：Cyclopropane Reaction Mechanisms、Catalytic C–H Functionalization Methods、Synthesis and Catalytic Reactions

An asymmetric three-component reaction via Mannich-type interception of an oxonium ylide with a 7-membered imine has been disclosed, providing chiral dibenzoazepine analogues with excellent stereoselectivity and structural diversity.