Processing speed dysfunction is associated with functional corticostriatal circuit alterations in childhood epilepsy with centrotemporal spikes: a PET and fMRI study

作者：Yuting Li, Teng Zhang, Jianhua Feng, Shufang Qian, Shuang Wu, Rui Zhou, Jing Wang, Guo Sa, Xiawan Wang, Lina Li, Feng Chen, Hong Yang, Hong Zhang, Mei Tian · 发表于：European Journal of Nuclear Medicine and Molecular Imaging · 年份：2022 · DOI：10.1007/s00259-022-05740-w · 被引用次数：17 · 研究领域：Functional Brain Connectivity Studies、Epilepsy research and treatment、Transcranial Magnetic Stimulation Studies

Abstract Purpose Epilepsy with centrotemporal spikes (ECTS) is the most common epilepsy syndrome in children and usually presents with cognitive dysfunctions. However, little is known about the processing speed dysfunction and the associated neuroimaging mechanism in ECTS. This study aims to investigate the brain functional abnormality of processing speed dysfunction in ECTS patients by using the 18 F-fluorodeoxyglucose ( 18 F-FDG) positron emission tomography (PET) and resting-state functional magnetic resonance imaging (rs-fMRI). Methods This prospective study recruited twenty-eight ECTS patients who underwent the 18 F-FDG PET, rs-fMRI, and neuropsychological examinations. Twenty children with extracranial tumors were included as PET controls, and 20 healthy children were recruited as MRI controls. The PET image analysis investigated glucose metabolism by determining standardized uptake value ratio (SUVR). The MRI image analysis explored abnormal functional connectivity (FC) within the cortical–striatal circuit through network-based statistical (NBS) analysis. Correlation analysis was performed to explore the relationship between SUVR, FC, and processing speed index (PSI). Results Compared with healthy controls, ECTS patients showed normal intelligence quotient but significantly decreased PSI ( P = 0.04). PET analysis showed significantly decreased SUVRs within bilateral caudate, putamen, pallidum, left NAc, right rostral middle frontal gyrus, and frontal pole of ECTS patie...