Minimizing treatment-induced emergence of antibiotic resistance in bacterial infections

作者：Mathew Stracy, Olga Snitser, Idan Yelin, Yara Amer, Miriam Parizade, Rachel Katz, Galit Rimler, Tamar Wolf, Esma Herzel, Gideon Koren, Jacob Kuint, Betsy Foxman, Gabriel Chodick, Varda Shalev, Roy Kishony · 发表于：Science · 年份：2022 · DOI：10.1126/science.abg9868 · 被引用次数：323 · 研究领域：Urinary Tract Infections Management、Antibiotic Resistance in Bacteria、Bacterial Identification and Susceptibility Testing

Treatment of bacterial infections currently focuses on choosing an antibiotic that matches a pathogen's susceptibility, with less attention paid to the risk that even susceptibility-matched treatments can fail as a result of resistance emerging in response to treatment. Combining whole-genome sequencing of 1113 pre- and posttreatment bacterial isolates with machine-learning analysis of 140,349 urinary tract infections and 7365 wound infections, we found that treatment-induced emergence of resistance could be predicted and minimized at the individual-patient level. Emergence of resistance was common and driven not by de novo resistance evolution but by rapid reinfection with a different strain resistant to the prescribed antibiotic. As most infections are seeded from a patient's own microbiota, these resistance-gaining recurrences can be predicted using the patient's past infection history and minimized by machine learning-personalized antibiotic recommendations, offering a means to reduce the emergence and spread of resistant pathogens.