Selective Synthesis of Substituted Pyridines and Pyrimidines through Cascade Annulation of Isopropene Derivatives

作者：Jian Li, Jiaming Li, Runfa He, Jiasheng Liu, Yang Liu, Lu Chen, Yubing Huang, Yibiao Li · 发表于：Organic Letters · 年份：2022 · DOI：10.1021/acs.orglett.2c00124 · 被引用次数：27 · 研究领域：Catalytic C–H Functionalization Methods、Cyclopropane Reaction Mechanisms、Synthesis and Catalytic Reactions

Diverse substituted pyridines and pyrimidines with high selectivity were obtained using a concise and efficient protocol developed herein. The reaction proceeds via metal-free cascade annulation of isopropene derivatives. Using isopropene derivatives as C3 synthons, NH 4 I as the “N” source, and formaldehyde or dimethyl sulfoxide as the carbon source, this reaction realizes the efficient formation of intermolecular C–N and C–C bonds.