Landscape of the RBD-specific IgG, IgM, and IgA responses triggered by the inactivated virus vaccine against the Omicron variant

作者：Jun-biao Xue, Dan‐yun Lai, He‐wei Jiang, Huan Qi, Shujuan Guo, Yuanshou Zhu, Hong Xu, Jie Zhou, Sheng‐ce Tao · 发表于：Cell Discovery · 年份：2022 · DOI：10.1038/s41421-022-00380-8 · 被引用次数：17 · 研究领域：SARS-CoV-2 and COVID-19 Research、Immunotherapy and Immune Responses、Animal Virus Infections Studies

The Omicron variant (B.1.1.529) possesses ~32 mutations in its spike protein, and at least 15 amino acid changes in the receptor-binding domain (RBD) 1 . The Omicron variant is worsening the COVID-19 pandemic largely due to the significant escape from the neutralization antibodies 2 . To combat the Omicron variant, one of the most effective methods is vaccination, including boosters. In China and some other countries, the dominant form of vaccine is derived from inactivated virus 3 . Further, in China, the vaccination campaign was carried out sequentially, starting from at-risk groups and big cities, and then on to the general public and smaller cities. Thus, across the country, there are many people at each of the different vaccination stages, namely unvaccinated, the 1st dose, the 2nd dose, and the 3rd (booster) dose. It is of great interest to know what level of protection that the inactivated virus vaccine can provide against the Omicron variant at each of these vaccination stages for rational optimization of vaccination strategies.