Data-driven study on resting-state functional magnetic resonance imaging during early abstinence of alcohol dependence in male patients and its predictive value for relapse

作者：Renhao Deng, Xia Yang, Yajing Meng, Yujie Tao, Hui-yao Wang, Xiaojing Li, Wei Wei, Hua Yu, Qiang Wang, Wei Deng, Liansheng Zhao, Xiaohong Ma, Mingli Li, Jiajun Xu, Jing Li, Yan‐Song Liu, Zhen Tang, Xiangdong Du, Jeremy Coid, Andrew J. Greenshaw, Tao Li, Wanjun Guo · 发表于：BMC Psychiatry · 年份：2022 · DOI：10.1186/s12888-022-03782-w · 被引用次数：22 · 研究领域：Functional Brain Connectivity Studies、Advanced Neuroimaging Techniques and Applications、Advanced MRI Techniques and Applications

BACKGROUND: Alcohol dependence is a mental disorder with a high relapse rate. However, specific neuroimaging biomarkers have not been determined for alcohol dependence and its relapse. We conducted data-driven research to investigate resting-state functional magnetic resonance imaging (rs-fMRI) during early abstinence from alcohol dependence and its potential ability to predict relapse. METHODS: Participants included 68 alcohol-dependent patients and 68 healthy controls (HCs). The regional homogeneity (ReHo) and fractional amplitude of low-frequency fluctuations (fALFF) were compared between the alcohol dependence group and the HCs and between the relapse group and the nonrelapse group. The brain regions that presented significantly different ReHo and/or fALFF between the alcohol-dependent patients and HCs and/or between the relapsed and nonrelapsed patients were selected as the seeds to calculate the functional connectivities (FCs). RESULTS: During a 6-month follow-up period, 52.24% of alcohol-dependent patients relapsed. A regression model for differentiating alcohol-dependent patients and HCs showed that reductions in ReHo in the left postcentral region, fALFF in the right fusiform region, and FC in the right fusiform region to the right middle cingulum were independently associated with alcohol dependence, with an area under the receiver operating characteristic curve (AUC) of 0.841. The baseline FC of the left precentral to the left cerebellum of the relapse group was si...