Higher uric acid serum levels are associated with sarcopenia in west China: a cross-sectional study

作者：Xiaolei Liu, Xiaoyan Chen, Fengjuan Hu, Xin Xia, Lisha Hou, Gongchang Zhang, Xuchao Peng, Xuelian Sun, Shuyue Luo, Jirong Yue, Birong Dong · 发表于：BMC Geriatrics · 年份：2022 · DOI：10.1186/s12877-022-02817-x · 被引用次数：49 · 研究领域：Nutrition and Health in Aging、Gout, Hyperuricemia, Uric Acid、Exercise and Physiological Responses

BACKGROUND: Sarcopenia is the decline in muscle strength and mass attributed to aging. The pathogenesis of sarcopenia may be triggered by oxidative stress and uric acid (UA) has strong antioxidant properties. The aim of this study was to investigate the relationship between UA and sarcopenia in community-dwelling adults of West China using the baseline data of West China Health and Aging Trend (WCHAT) study. DESIGN: A cross-sectional study. METHODS: 4236 adults aged 50 years or older in communities of west China were enrolled in this study. We applied Asian Working Group for Sarcopenia (AWGS) 2019 criteria to define sarcopenia. Muscle mass was measured using skeletal muscle index (SMI) based on bioimpedance analysis (BIA). Handgrip strength (HGS) and gait speed (GS) were recorded, respectively. Different variables like anthropometry measures, life styles, chronic disease and blood test were collected. General linear model was done to investigate the relationship between UA and HGS/GS/SMI, adjusting age, ethnic groups, sleeping quality, education level, cognitive function, smoking history, drinking history, ADL score, and chronic disease. RESULTS: Participants were grouped according to UA quartiles by gender. After adjusting for potential confounders, a negative association between serum UA levels and sarcopenia was shown both in men and women. And a significant association between serum UA levels and HGS in women was shown as an inverted J shape. Besides, a positive associati...