Cubic multi-ions-doped Na2TiO3 nanorod-like coatings: Structure-stable, highly efficient platform for ions-exchanged release to immunomodulatory promotion on vascularized bone apposition

作者：Dongmei Yu, Bo Li, Meng Yu, Shuo Guo, Zheng Guo, Zheng Guo, Yong Han · 发表于：Bioactive Materials · 年份：2022 · DOI：10.1016/j.bioactmat.2022.01.039 · 被引用次数：28 · 研究领域：Bone Tissue Engineering Materials、Marine Biology and Environmental Chemistry、Bone Metabolism and Diseases

The dissolution-derived release of bioactive ions from ceramic coatings on metallic implants, despite improving osseointegration , renders a concern on the interfacial breakdown of the metal/coating/bone system during long-term service. Consequently, persistent efforts to seek alternative strategies instead of dissolution-derived activation are pressingly carrying out. Inspired by bone mineral containing ions as Ca 2+ , Mg 2+ , Sr 2+ and Zn 2+ , here we hydrothermally grew the quadruple ions co-doped Na 2 TiO 3 nanorod-like coatings. The co-doped ions partially substitute Na + in Na 2 TiO 3 , and can be efficiently released from cubic lattice via exchange with Na + in fluid rather than dissolution, endowing the coatings superior long-term stability of structure and bond strength . Regulated by the coatings-conditioned extracellular ions, TLR4-NFκB signalling is enhanced to act primarily in macrophages (MΦs) at 6 h while CaSR-PI3K-Akt1 signalling is potentiated to act predominately since 24 h, triggering MΦs in a M1 response early and then in a M2 response to sequentially secrete diverse cytokines. Acting on endothelial and mesenchymal stem cells with the released ions and cytokines, the immunomodulatory coatings greatly promote Type-H (CD31 hi Emcn hi ) angiogenesis and osteogenesis in vitro and in vivo , providing new insights into orchestrating insoluble ceramics-coated implants for early vascularized osseointegration in combination with long-term fixation to bone.