Gut-brain axis: Focus on gut metabolites short-chain fatty acids

作者：Cen Guo, Yajing Huo, Yu Li, Yan Ping Han, Da Zhou · 发表于：World Journal of Clinical Cases · 年份：2022 · DOI：10.12998/wjcc.v10.i6.1754 · 被引用次数：95 · 研究领域：Gut microbiota and health、Diet and metabolism studies、Tryptophan and brain disorders

multiple pathways related to neuroendocrine, immune, and neural pathways, thereby proposing the new concept of the microbiome-gut-brain (MGB) axis. Recently, the role of short-chain fatty acids (SCFAs), which are the main anaerobic fermented metabolites of the gut microbiota in the MGB axis, has garnered significant attention. SCFAs are involved in a broad range of central neurological diseases, including neurodegenerative diseases, cerebral vascular diseases, epilepsy, neuroimmune inflammatory diseases, and mood disorders. However, the underlying mechanism of SCFA-related distant organ crosstalk is yet to be elucidated. Herein, we summarize current knowledge regarding interactions between SCFAs and the MGB axis, as well as their protective effects against central neurological diseases.