Omicron adopts a different strategy from Delta and other variants to adapt to host

作者：Xiaohong Du, Haijun Tang, Long Gao, Zhao Wu, Fang Meng, Ruhong Yan, Shigang Qiao, Jianzhong An, Chen Wang, F. Xiao‐Feng Qin · 发表于：Signal Transduction and Targeted Therapy · 年份：2022 · DOI：10.1038/s41392-022-00903-5 · 被引用次数：103 · 研究领域：SARS-CoV-2 and COVID-19 Research、Molecular Communication and Nanonetworks、CAR-T cell therapy research

With the ongoing of Corona Virus Disease 2019 (COVID-19) epidemic, new strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are continuously emerging. After Delta (B.1.617.2) identified in India, Lambda (C.37), Mu (B.1.621), and Omicron (B.1.1.529) were successively found in Peru, Colombia, and Botswana/South Africa, and subsequently defined as variant of interest (VOI) or variant of concern (VOC). Three VOC strains (Alpha (B.1.1.7), Beta (B.1.351), and Delta) caused the first three waves of global epidemics. However, as the leading variant of the fourth wave of epidemic, the character of Omicron strain is still elusive. Here, we systematically characterized the infectivity, thermal stability, proteolytic activation, entry path, fusogenicity, and immune response of Lambda, Mu, and Omicron variants.