AMPK and the Adaptation to Exercise

作者：Hannah Rose Spaulding, Zhen Yan · 发表于：Annual Review of Physiology · 年份：2022 · DOI：10.1146/annurev-physiol-060721-095517 · 被引用次数：220 · 研究领域：Metabolism, Diabetes, and Cancer、Adipose Tissue and Metabolism、Pancreatic function and diabetes

Noncommunicable diseases are chronic diseases that contribute to death worldwide, but these diseases can be prevented and mitigated with regular exercise. Exercise activates signaling molecules and the transcriptional network to promote physiological adaptations, such as fiber type transformation, angiogenesis, and mitochondrial biogenesis. AMP-activated protein kinase (AMPK) is a master regulator that senses the energy state, promotes metabolism for glucose and fatty acid utilization, and mediates beneficial cellular adaptations in many vital tissues and organs. This review focuses on the current, integrative understanding of the role of exercise-induced activation of AMPK in the regulation of system metabolism and promotion of health benefits.