Development of the human heart

作者：Marieke F.J. Buijtendijk, Phil Barnett, Maurice J.B. van den Hoff · 发表于：American Journal of Medical Genetics Part C Seminars in Medical Genetics · 年份：2020 · DOI：10.1002/ajmg.c.31778 · 被引用次数：181 · 研究领域：Congenital heart defects research、Congenital Heart Disease Studies、Genetics and Neurodevelopmental Disorders

Abstract In 2014, an extensive review discussing the major steps of cardiac development focusing on growth, formation of primary and chamber myocardium and the development of the cardiac electrical system, was published. Molecular genetic lineage analyses have since furthered our insight in the developmental origin of the various component parts of the heart, which currently can be unambiguously identified by their unique molecular phenotype. Moreover, genetic, molecular and cell biological analyses have driven insights into the mechanisms underlying the development of the different cardiac components. Here, we build on our previous review and provide an insight into the molecular mechanistic revelations that have forwarded the field of cardiac development. Despite the enormous advances in our knowledge over the last decade, the development of congenital cardiac malformations remains poorly understood. The challenge for the next decade will be to evaluate the different developmental processes using newly developed molecular genetic techniques to further unveil the gene regulatory networks operational during normal and abnormal cardiac development.