Positive H. pylori status predicts better prognosis of non-cardiac gastric cancer patients: results from cohort study and meta-analysis

作者：Zhifang Jia, Min Zheng, Jing Jiang, Donghui Cao, Yanhua Wu, Yuzheng Zhang, Yingli Fu, Xueyuan Cao · 发表于：BMC Cancer · 年份：2022 · DOI：10.1186/s12885-022-09222-y · 被引用次数：24 · 研究领域：Helicobacter pylori-related gastroenterology studies、Gastric Cancer Management and Outcomes、Galectins and Cancer Biology

Abstract Background Previous researches have associated Helicobacter pylori ( H. pylori ) with a prognosis of gastric cancer (GC), however, without a concert conclusion. This study aimed to study this issue further by a prospective cohort study and a meta-analysis. Methods Histologically diagnosed gastric cancer (GC) patients were recruited into the primary prospective cohort study between January 2009 to December 2013. All the patients were followed-up periodically to record information on post-surgery therapy and overall survival status. The pre-surgery status of H. pylori was measured by enzyme-linked immunosorbent assay. A meta-analysis was conducted after retrieving related researches in the databases of PubMed and Embase up to April 2020. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were summarized to validate the relationship between H. pylori infection and the survival time of GC patients. I 2 statistics and Q test were used to assess the heterogeneity. Sensitivity analyses were performed using Galbraith’s plot, leave-one-out analysis, subgroup analyses and meta-regression to explore the sources of heterogeneity and the stability of the summary results. Results A total of 743 GC patients with radical tumorectomy were included prospectively and 516 (69.4%) were positive on H. pylori . H. pylori -positive patients tended to survive longer than -negative ones (HR 0.92, 95%CI: 0.74–1.15), though the tendency was not statistically significant. Cohort studi...