[Complex network analysis on regularities of acupoint combinations and application characteristics of acupuncture and moxibustion in the treatment of knee osteoarthritis].

作者：Rui‐Han Wang, Pingju Xue, Hai-Jiao Xing, Chun‐Sheng Jia, Jing Shi · 发表于：PubMed · 年份：2022 · DOI：10.13702/j.1000-0607.20210080 · 被引用次数：7 · 研究领域：Acupuncture Treatment Research Studies、Medical Research and Treatments、Traditional Chinese Medicine Studies

OBJECTIVE: To analyze the regularities of combination of acupoints in the existing clinical trial literature by using complex network technique, so as to provide reliable evidence for selecting appropriate acupoint recipes in the treatment of knee osteoarthritis (KOA) with acupuncture and moxibustion therapies. METHODS: Clinical papers about acupuncture treatment of KOA published from January of 2000 to April of 2020 were searched from Chinese and English databases including CNKI, Wanfang, VIP, Pubmed and ScienceDirect by using keywords of "acupuncture", "moxibustion" and "knee osteoarthritis". According to the inclusive and exclusive criteria, the collected papers were screened out to set up a database. SPSS Modeler18.0 software was used to analyze the association rules of acupoints (including the core acupoint nodes and compatibility relationship), and Gephi0.9.2 software was employed to conduct a complex network analysis about the compatibility rules of acupoints and their application characteristics of moxibustion and needling methods in the treatment of KOA (shown by a complex network schematic diagram). RESULTS: A total of 444 acupuncture prescriptions were extracted, including 6 single-acupoint prescriptions (1.35%) and 438 multiple-acupoint prescriptions (98.65%). A total of 112 acupoints were involved, with the application frequency of 3 389. Among them, the application frequency of the Neixiyan (EX-LE4)is the highest (354 times, 10.45%), followed by Dubi (ST35), Xue...