Intermittent Theta Burst Stimulation Increases Natural Oscillatory Frequency in Ipsilesional Motor Cortex Post-Stroke: A Transcranial Magnetic Stimulation and Electroencephalography Study

作者：Qian Ding, Songbin Chen, Jixiang Chen, Shunxi Zhang, Yuan Peng, Yujie Chen, Junhui Chen, Xiaotong Li, Kang Chen, Guiyuan Cai, Guangqing Xu, Yue Lan · 发表于：Frontiers in Aging Neuroscience · 年份：2022 · DOI：10.3389/fnagi.2022.818340 · 被引用次数：26 · 研究领域：Transcranial Magnetic Stimulation Studies、Stroke Rehabilitation and Recovery、EEG and Brain-Computer Interfaces

Objective Intermittent theta burst stimulation (iTBS) has been widely used as a neural modulation approach in stroke rehabilitation. Concurrent use of transcranial magnetic stimulation and electroencephalography (TMS-EEG) offers a chance to directly measure cortical reactivity and oscillatory dynamics and allows for investigating neural effects induced by iTBS in all stroke survivors including individuals without recordable MEPs. Here, we used TMS-EEG to investigate aftereffects of iTBS following stroke. Methods We studied 22 stroke survivors (age: 65.2 ± 11.4 years; chronicity: 4.1 ± 3.5 months) with upper limb motor deficits. Upper-extremity component of Fugl-Meyer motor function assessment and action research arm test were used to measure motor function of stroke survivors. Stroke survivors were randomly divided into two groups receiving either Active or Sham iTBS applied over the ipsilesional primary motor cortex. TMS-EEG recordings were performed at baseline and immediately after Active or Sham iTBS. Time and time-frequency domain analyses were performed for quantifying TMS-evoked EEG responses. Results At baseline, natural frequency was slower in the ipsilesional compared with the contralesional hemisphere ( P = 0.006). Baseline natural frequency in the ipsilesional hemisphere was positively correlated with upper limb motor function following stroke ( P = 0.007). After iTBS, natural frequency in the ipsilesional hemisphere was significantly increased ( P < 0.001)...