Sex Differences in Short-Term and Long-Term Outcomes Among Patients With Acute Ischemic Stroke in China

作者：Meng Wang, Chun-Juan Wang, Hong-Qiu Gu, Xia Meng, Yong Jiang, Xin Yang, Jing Zhang, Yun-Yun Xiong, Xing-Quan Zhao, Li-Ping Liu, Yi-Long Wang, Yong-Jun Wang, Zi-Xiao Li · 发表于：Stroke · 年份：2022 · DOI：10.1161/strokeaha.121.037121 · 被引用次数：72 · 研究领域：Acute Ischemic Stroke Management、Acute Myocardial Infarction Research、Stroke Rehabilitation and Recovery

BACKGROUND: Sex differences in stroke outcomes are crucial to secondary prevention, but previous reports showed inconsistent results. We aimed to explore the sex differences in stroke outcomes in the Third China National Stroke Registry, a prospective multicenter registry study. METHODS: Among the 15 166 patients enrolled between 2015 and 2018, 9038 patients with acute ischemic stroke (AIS) were included. The primary outcomes were stroke recurrence, mortality, and unfavorable functional outcome (modified Rankin Scale > 2) at 3, 6, and 12 months. Cox regression model was used for stroke recurrence and mortality and logistic regression was used for the unfavorable functional outcome, and adjusted as follows: (1) Model 1: without adjustment; (2) Model 2: adjusted for potential risk factors, National Institutes of Health Stroke Scale at admission, prestroke modified Rankin Scale, tPA (tissue-type plasminogen activator) treatment, TOAST (Trial of ORG 10172 in Acute Stroke Treatment) classification, and onset-to-door time; (3) Model 3: adjusted for covariates from model 2 in addition to blood pressure and blood serum covariates. Multiple imputation was used for missing values, and sensitivity analyses were conducted to describe sex differences by age groups. RESULTS: <0.001). In the fully adjusted model, female patients were more likely to have unfavorable functional outcomes at 3 months (odds ratio, 1.28 [1.09-1.50]), especially among patients aged 65 years or older (odds ratio, 1...