Environmental and sensitization variations among asthma and/or rhinitis patients between 2008 and 2018 in China

作者：Wanjun Wang, Jianhong Wang, Guihua Song, Hua Xie, Xiaoping Lin, Ruonan Chai, Rongfei Zhu, Yong He, Jun Tang, Junge Wang, Jinghua Yang, Lili Zhi, Lin Wu, Yan Jiang, Xiaoqin Zhou, Dongming Huang, Ning Wang, Rui Xu, Yuan Gao, Zhimin Chen, Jinling Liu, Xiaoli Han, Guolin Tan, Jinzhun Wu, Deyu Zhao, Jianjun Chen, Xiwei Zhang, Mengrong Li, Yuemei Sun, Yi Jiang, Weitian Zhang, Qianhui Qiu, Chuanhe Liu, Jie Yin, Guodong Hao, Huabin Li, Yongsheng Xu, Shaohua Chen, Hua Zhang, Shi Chen, Juan Meng, Dan Zeng, Wei Tang, Chuangli Hao, Jing Li, Nanshan Zhong · 发表于：Clinical and Translational Allergy · 年份：2022 · DOI：10.1002/clt2.12116 · 被引用次数：44 · 研究领域：Allergic Rhinitis and Sensitization、Asthma and respiratory diseases、Dermatology and Skin Diseases

Abstract Background Little is known about the changes in allergen sensitization in China secondary to the environmental variations over the past decade. We aimed at investigating the variations in sensitization among asthma and/or rhinitis patients in China between 2008 and 2018. Methods This study analyzed cross‐sectional data from national surveys conducted in China in 2008 and 2018. After finishing the questionnaire, participants underwent serum specific IgE measurements. A total of 2322 and 2798 patients were enrolled in 2008 and 2018, respectively. The significance of differences in sensitization rates among four regions of China were assessed. Correlation analysis was used to identify the associations of sensitization with climate change and planting of Artemisia desertorum between the two surveys. Results Compared with 2008, the general sensitization rate to mites significantly increased in 2018, which ranked highest among all tested allergens. Sensitization to pollens, especially Artemisia vulgaris , showed the greatest increase in the north. The annual mean temperature, rainfall and relative humidity in all four regions, and the Artemisia desertorum coverage in the northeastern area, increased significantly in 2018 as compared with 2008. From 2008 to 2018, an increase in Dermatophagoides pteronyssinus sensitization was significantly associated with an increase in relative humidity ( r = 0.54, p = 0.037). The increase in A. vulgaris sensitization was significantly ass...