Enduring effect of abuse: Childhood maltreatment links to altered theory of mind network among adults

作者：Yajing Pang, Shanshan Zhao, Zhihui Li, Nan Li, Jiarui Yu, Rui Zhang, Fengmei Lu, Heng Chen, Fengchun Wu, Wei Zheng, Jingjing Gao, Yongfeng Yang, Huawang Wu, Jiaojian Wang · 发表于：Human Brain Mapping · 年份：2022 · DOI：10.1002/hbm.25787 · 被引用次数：37 · 研究领域：Child Abuse and Trauma、Child and Adolescent Psychosocial and Emotional Development、Maternal Mental Health During Pregnancy and Postpartum

Childhood maltreatment (CM) confers a great risk of maladaptive development outcomes later in life, however, the neurobiological mechanism underlying this vulnerability is still unclear. The present study aimed to investigate the long-term consequences of CM on neural connectivity while controlling for psychiatric conditions, medication, and, substance abuse. A sample including adults with (n = 40) and without CM (n = 50) completed Childhood Trauma Questionnaire (CTQ), personality questionnaires, and resting-state functional magnetic resonance imaging scan were recruited for the current study. The whole-brain functional connectivity (FC) was evaluated using an unbiased, data-driven, multivariate pattern analysis method. Relative to controls, adults with CM suffered a higher level of temperament and impulsivity and showed decreased FC between the insula and superior temporal gyrus (STG) and between inferior parietal lobule (IPL) and middle frontal gyrus, STG, and dorsal anterior cingulate cortex (dACC), while increased FC between IPL and cuneus and superior frontal gyrus (SFG) regions. The FCs of IPL with dACC and SFG were correlated with the anxious and cyclothymic temperament and attentional impulsivity. Moreover, these FCs partially mediated the relationship between CM and attentional impulsivity. Our results suggest that CM has a significant effect on the modulation of FC within theory of mind (ToM) network even decades later in adulthood, and inform a new framework to acc...