Role of Thymus and Activation-Regulated Chemokine in Allergic Asthma

作者：Quang Luu Quoc, Ji-Young Moon, Dong-Hyun Lee, Ga-Young Ban, Seung-Hyun Kim, Hae-Sim Park · 发表于：Journal of Asthma and Allergy · 年份：2022 · DOI：10.2147/jaa.s351720 · 被引用次数：21 · 研究领域：Asthma and respiratory diseases、Mast cells and histamine、Cytokine Signaling Pathways and Interactions

Background: Asthma is a chronic inflammatory airway disease characterized by the predominant infiltration of inflammatory cells in the airways. Thymus and activation-regulated chemokine/C–C motif chemokine 17 (TARC/CCL17) is a chemokine responsible for trafficking T helper 2 cells into sites of allergic inflammation. Objective: To validate the role of TARC in association with clinical and inflammatory parameters in adult asthmatics. Methods: We enrolled 128 asthmatic patients and 70 healthy controls (HCs). Asthma-related clinical and laboratory parameters, including lung function and eosinophil counts, were measured. Serum levels of TARC, free immunoglobulin E (IgE), and eosinophil-derived neurotoxin (EDN) were determined by using enzyme-linked immunosorbent assay; serum total IgE level was measured using ImmunoCAP. The levels of inflammatory lipid mediators, such as leukotriene E4 (LTE4), 15-hydroxyeicosatetraenoic acid (15-HETE), thromboxane B2 (TXB2), and prostaglandin F2α (PGF2α), were measured by liquid chromatography-tandem mass spectrometry. Results: Serum TARC levels are significantly higher in asthmatics than in HCs and in allergic asthmatics than in HCs ( P < 0.010 for all), with significantly negative correlations between serum TARC levels and FEV 1 %/MMEF% values ( r = − 0.314, r = − 0.268, P < 0.050 for both). The patients with higher serum TARC levels had higher levels of serum total and free IgE levels ( P < 0.050 for both) with positive correlations to serum l...