Palladium-Catalyzed Carbene Migratory Insertion/Carbonylation Cascade Reaction: Synthesis of 2-Indolones with a C3 All-Carbon Quaternary Center

作者：Ming Cheng, Xiaoyan Huang, Fang Yang, Dongmei Zhao, Ke‐Gong Ji, Zi‐Sheng Chen · 发表于：Organic Letters · 年份：2022 · DOI：10.1021/acs.orglett.2c00073 · 被引用次数：15 · 研究领域：Cyclopropane Reaction Mechanisms、Catalytic C–H Functionalization Methods、Catalytic Cross-Coupling Reactions

An attractive palladium-catalyzed three-component reaction of ortho -amino aryl diazo esters, allyl carboxylates, and carbon monoxide (CO) has been developed. This catalytic system rendered domino carbene migratory insertion and carbonylation. Remarkably, 2-indolones 3 with a C3 all-carbon quaternary center can be selectively obtained in good to excellent yields via one-pot synthesis, in which two different C–C bonds and one C–N bond were formed in a straightforward manner.