Akkermansia muciniphila Ameliorates Acetaminophen-Induced Liver Injury by Regulating Gut Microbial Composition and Metabolism

作者：Jiafeng Xia, Longxian Lv, Boqiang Liu, Shuting Wang, Sitong Zhang, Zhengjie Wu, Liya Yang, Xiaoyuan Bian, Qiangqiang Wang, Kaicen Wang, Aoxiang Zhuge, Shengjie Li, Yan Ren, Huiyong Jiang, Kaijin Xu, Lanjuan Li · 发表于：Microbiology Spectrum · 年份：2022 · DOI：10.1128/spectrum.01596-21 · 被引用次数：172 · 研究领域：Drug-Induced Hepatotoxicity and Protection、Tryptophan and brain disorders、Gut microbiota and health

Our work revealed that A. muciniphila attenuated APAP-induced liver injury by alleviating oxidative stress and inflammation in the liver, and its hepatoprotective effect was accompanied by activation of the PI3K/Akt pathway and mediated by regulation of the composition and metabolic function of the intestinal microbiota. This finding suggested that the microbial community is a non-negligible impact on drug metabolism and probiotic administration could be a potential therapy for drug-induced liver injury.