P2X7Rs: new therapeutic targets for osteoporosis

作者：Haoyun Huang, HE Yu-mei, Miaomiao Lin, Yanchao Wang, Xiaomei Zhang, Liang Li, Xueling He · 发表于：Purinergic Signalling · 年份：2022 · DOI：10.1007/s11302-021-09836-0 · 被引用次数：19 · 研究领域：Adenosine and Purinergic Signaling、Neurological Complications and Syndromes、Pregnancy and Medication Impact

Increasing evidence suggests that both the occurrence and progression of osteoporosis are associated with inflammation, especially in primary osteoporosis. The maintenance of skeletal homeostasis is dependent on the complex regulation of bone metabolism. Numerous evidence suggested that purinoceptor networks are essential for bone homeostasis. In this review, the relationship between inflammation and the development of osteoporosis and the role of P2X7 receptor (P2X7R) in regulating the dynamic regulation of bone reconstruction were covered. We also discussed how P2X7R regulates the balance between resorption and bone formation by osteoblasts and reviewed the relevance of P2X7R polymorphisms in skeletal physiology. Finally, we analyzed potential targets of P2X7R for osteoporosis.