Exotoxin-Targeted Drug Modalities as Antibiotic Alternatives

作者：Moona Sakari, Arttu Laisi, Arto T. Pulliainen · 发表于：ACS Infectious Diseases · 年份：2022 · DOI：10.1021/acsinfecdis.1c00296 · 被引用次数：35 · 研究领域：Toxin Mechanisms and Immunotoxins、Clostridium difficile and Clostridium perfringens research、Bacillus and Francisella bacterial research

), but also to challenges with some of the promising leads. We also highlight the recent developments in pre-clinical research sector to develop exotoxin-targeted drug modalities, i.e., monoclonal antibodies, antibody fragments, antibody mimetics, receptor analogs, neutralizing scaffolds, dominant-negative mutants, and small molecules. We describe how these exotoxin-targeted drug modalities work with high-resolution structural knowledge and highlight their advantages and disadvantages as antibiotic alternatives.