The Pfam protein families database

作者：Alex Bateman · 发表于：Nucleic Acids Research · 年份：2003 · DOI：10.1093/nar/gkh121 · 被引用次数：3216 · 研究领域：Advanced Proteomics Techniques and Applications、Enzyme Structure and Function、Forensic and Genetic Research

Pfam is a large collection of protein families and domains. Over the past 2 years the number of families in Pfam has doubled and now stands at 6190 (version 10.0). Methodology improvements for searching the Pfam collection locally as well as via the web are described. Other recent innovations include modelling of discontinuous domains allowing Pfam domain definitions to be closer to those found in structure databases. Pfam is available on the web in the UK (http://www.sanger.ac.uk/Software/Pfam/), the USA (http://pfam.wustl.edu/), France (http://pfam.jouy.inra.fr/) and Sweden (http://Pfam.cgb.ki.se/).