Heterotopic Ossification: Clinical Features, Basic Researches, and Mechanical Stimulations

作者：Yili Xu, Mei Huang, Wenzhen He, Chen He, Kaixuan Chen, Jing Hou, Min Huang, Yurui Jiao, Ran Liu, Nan-Yu Zou, Ling Liu, Changjun Li · 发表于：Frontiers in Cell and Developmental Biology · 年份：2022 · DOI：10.3389/fcell.2022.770931 · 被引用次数：65 · 研究领域：Heterotopic Ossification and Related Conditions、Genetic Syndromes and Imprinting、Cervical and Thoracic Myelopathy

Heterotopic ossification (HO) is defined as the occurrence of extraskeletal bone in soft tissue. Although this pathological osteogenesis process involves the participation of osteoblasts and osteoclasts during the formation of bone structures, it differs from normal physiological osteogenesis in many features. In this article, the primary characteristics of heterotopic ossification are reviewed from both clinical and basic research perspectives, with a special highlight on the influence of mechanics on heterotopic ossification, which serves an important role in the prophylaxis and treatment of HO.