Clinicopathological Profile and Outcome of a Large Cohort of Patients with Nonalcoholic Fatty Liver Disease from South Asia: Interim Results of the Indian Consortium on Nonalcoholic Fatty Liver Disease

作者：Ajay Kumar. Duseja, Shivaram Prasad Singh, Manu Mehta, S. Shalimar, Jayanthi Venkataraman, Varun Mehta, Krishnadas Devadas, Sanjib Kumar Kar, Omesh Goyal, Aabha S. Nagral, Sanjiv Saigal, Sandeep Nijhawan, Dibya Lochan Praharaj, Akash Shukla, Brij Sharma, Krishnasamy Narayanasamy, Pramod Kumar, Padaki Nagaraja Rao, Anil Arora, Rajiv M Mehta, Pankaj Asati, Piyush Ranjan, Abraham Koshy, Seema Alam, Shrikant V Mukewar, Saurabh S. Mukewar, Virukalpatti Gopalratnam Mohan Prasad, Mukul Rastogi, Arun Jayant Sanyal, on behalf of ICON-D Study Group · 发表于：Metabolic Syndrome and Related Disorders · 年份：2022 · DOI：10.1089/met.2021.0104 · 被引用次数：35 · 研究领域：Liver Disease Diagnosis and Treatment、Diet, Metabolism, and Disease、Liver Disease and Transplantation

Background: Previous data from South Asia and India had shown that patients with nonalcoholic fatty liver disease (NAFLD) have mild liver disease severity. There are no data regarding long-term clinical outcomes in patients with NAFLD from South Asia. The aim of the study was to evaluate the clinicopathological profile, severity of NAFLD, and clinical outcomes in a large cohort of patients with NAFLD from South Asia. Methods: In an ongoing real-life study [Indian Consortium on nonalcoholic fatty liver disease (ICON-D)], interim data captured across 23 centers in India over 18 months was analyzed for clinicopathological profile, severity of NAFLD, and hepatic/extrahepatic events on follow-up. Results: Of 4313 patients (mean age 45 ± 12.2 years, males 52%), data on metabolic risk factors in 3553 (82.3%) patients revealed that 378 (10.6%) were lean, 575 (16.2%) overweight, 2584 (72.7%) obese; metabolic syndrome in 1518 (42.7%) and at least one metabolic risk factor in 3292 (92.6%) patients. Evidence of significant or advanced fibrosis assessed with [aspartate transaminase to platelet ratio index (APRI), n = 3196 (74%)], [fibrosis-4 (FIB-4), n = 3554 (82.4%)], [NAFLD fibrosis score (NFS), n = 1924 (44.6%)], [Fibroscan, n = 2475, (57.3%)], and histology [n = 267 (6.2%)] was present in 682 (21.3%), 676 (19%), 397 (20.6%), 715 (29%), and 41 (15.4%) patients, respectively; 246 (10%) patients on Fibroscan and 22 (8.2%) on histology had evidence of cirrhosis. On a mean follow-up 43.5 m...