Elevated resting heart rates are a risk factor for mortality among patients with coronavirus disease 2019 in Wuhan, China

作者：Han Jin, Shengwen Yang, Fan Yang, Long Zhang, Haoyu Weng, Shengcong Liu, Fangfang Fan, Haichao Li, Xizi Zheng, Hongyu Yang, Yan Zhang, Jing Zhou, Jianping Li · 发表于：Journal of Translational Internal Medicine · 年份：2021 · DOI：10.2478/jtim-2021-0042 · 被引用次数：10 · 研究领域：Heart rate and cardiovascular health、Heart Rate Variability and Autonomic Control、COVID-19 Clinical Research Studies

ABSTRACT Background: We evaluated the association between higher resting heart rates (RHRs) and adverse events in COVID-19 patients. Methods: One hundred and thirty-six patients with laboratory-confirmed COVID-19 were admitted. Outcomes of patients with different RHRs were compared. Results: Twenty-nine patients had RHRs of <80 bpm (beat per min), 85 had 80–99 bpm and 22 had ≥100 bpm as tachycardia. Those with higher RHRs had lower pulse oxygen saturation (SpO 2 ) and higher temperatures, and there was a higher proportion of men upon admission (all P < 0.05). Patients with higher RHRs showed higher white blood cell counts and D-dimer, cardiac troponin I (TnI), N-terminal pro-B-type natriuretic peptide and hypersensitive C-reactive protein levels, but lower albumin levels (all P < 0.05) after admission. During follow-up, 26 patients died (mortality rate, 19.1%). The mortality rate was significantly higher among patients with tachycardia than among the moderate and low RHR groups (all P < 0.001). Kaplan–Meier survival curves showed that the risks of death and ventilation use increased for patients with tachycardia ( P < 0.001). Elevated RHR as a continuous variable and a mean RHR as tachycardia were independent risk factors for mortality and ventilator use (all P < 0.05) in the multivariable adjusted Cox proportional hazards regression model. Conclusions: Elevated average RHRs during the first 3 days of hospitalisation were associated with adverse outcomes in ...