Migraine Is More Prevalent in Advanced-Stage Endometriosis, Especially When Co-Occuring with Adenomoysis

作者：Yingchen Wu, Hao Wang, Shengfu Chen, Yueming Lin, Xiaoqian Xie, Guangzheng Zhong, Qingxue Zhang · 发表于：Frontiers in Endocrinology · 年份：2022 · DOI：10.3389/fendo.2021.814474 · 被引用次数：32 · 研究领域：Endometriosis Research and Treatment、Migraine and Headache Studies、Maternal Mental Health During Pregnancy and Postpartum

Background: Emerging data suggest a significant association between migraine and endometriosis, however the relationship between migraine and endometriosis severity or adenomyosis is unclear. Our objectives were to explore the relationship between migraine and endometriosis, according to the endometriosis severity and co-exist with adenomyosis or not. Methods: This case-control study of 167 endometriosis patients verified by surgery and 190 patients for other benign gynecological conditions (control subjects) was performed from September 2017 and January 2021. There is 49 adenomyosis detected by transvaginal ultrasound or histologic diagnosis among the endometriosis patients. Besides, we also included 41 adenomyosis but without endometriosis patients as a subgroup. All women completed a self-administered headache questionnaire and diagnosed as migraine according to the International Headache Society classification. The severity and stage of endometriosis was evaluated with revised American Society of Reproductive Medicine (rASRM) score. We used logistic regression to estimate the association between the presence of migraine and endometriosis severity while accounting for important confounders, including age, body mass index (BMI) and family history of migraine. We also estimate the risk of adenomyosis alone and adenomyosis with co-occurring endometriosis in migrainous women. Results: >0.05). For all endometriosis and control participants, migraineurs were 4.6-times (OR=4.6; 9...