Myocarditis Cases Reported After mRNA-Based COVID-19 Vaccination in the US From December 2020 to August 2021

作者：Matthew E. Oster, David K. Shay, John R. Su, Julianne M. Gee, Clarence Buddy Creech, Karen R. Broder, Kathryn M. Edwards, Jonathan H. Soslow, Jeffrey M. Dendy, Elizabeth P. Schlaudecker, Sean M. Lang, Elizabeth D. Barnett, Frederick L. Ruberg, Michael J. Smith, Michael Jay Campbell, Renato D. Lópes, Laurence S. Sperling, Jane A. Gwira Baumblatt, Deborah Thompson, Paige L. Marquez, Penelope Strid, Jared Woo, River A. Pugsley, Sarah Reagan-Steiner, Frank DeStefano, Tom T. Shimabukuro · 发表于：JAMA · 年份：2022 · DOI：10.1001/jama.2021.24110 · 被引用次数：694 · 研究领域：Viral Infections and Immunology Research、SARS-CoV-2 and COVID-19 Research、Animal Virus Infections Studies

Importance: Vaccination against COVID-19 provides clear public health benefits, but vaccination also carries potential risks. The risks and outcomes of myocarditis after COVID-19 vaccination are unclear. Objective: To describe reports of myocarditis and the reporting rates after mRNA-based COVID-19 vaccination in the US. Design, Setting, and Participants: Descriptive study of reports of myocarditis to the Vaccine Adverse Event Reporting System (VAERS) that occurred after mRNA-based COVID-19 vaccine administration between December 2020 and August 2021 in 192 405 448 individuals older than 12 years of age in the US; data were processed by VAERS as of September 30, 2021. Exposures: Vaccination with BNT162b2 (Pfizer-BioNTech) or mRNA-1273 (Moderna). Main Outcomes and Measures: Reports of myocarditis to VAERS were adjudicated and summarized for all age groups. Crude reporting rates were calculated across age and sex strata. Expected rates of myocarditis by age and sex were calculated using 2017-2019 claims data. For persons younger than 30 years of age, medical record reviews and clinician interviews were conducted to describe clinical presentation, diagnostic test results, treatment, and early outcomes. Results: Among 192 405 448 persons receiving a total of 354 100 845 mRNA-based COVID-19 vaccines during the study period, there were 1991 reports of myocarditis to VAERS and 1626 of these reports met the case definition of myocarditis. Of those with myocarditis, the median age was...