Water extract of Ferula lehmanni Boiss. prevents high-fat diet-induced overweight and liver injury by modulating the intestinal microbiota in mice

作者：Yuting Ye, Lin Shi, Peng Wang, Minmin Yang, Ping Zhan, Honglei Tian, Jianshu Liu · 发表于：Food & Function · 年份：2022 · DOI：10.1039/d1fo03518e · 被引用次数：11 · 研究领域：Liver Disease Diagnosis and Treatment、Diet, Metabolism, and Disease、Tea Polyphenols and Effects

spp. and so on, thereby reversing the detrimental effects of HFD in mice. Removal of the gut microbiota with antibiotics partially eliminated the hepatoprotective effects of WEFL. Notably, WEFL substantially promoted the levels of short-chain fatty acids, especially butyric acid. To clarify the functional components at play in WEFL, we used UPLC-MS/MS to comprehensively detect its substance composition and found it to be a collection of polyphenol-rich compounds. Together, our findings demonstrate that WEFL prevented HFD-induced obesity and liver injury through the hepatic-microbiota axis, and such health-promoting value might be explained by the enriched abundant polyphenols.