Decreased Serum Maresin 1 Concentration Is Associated With Postmenopausal Osteoporosis: A Cross-Sectional Study

作者：Jing Wu, Xinyue Li, Fang Xia, Fang‐Yuan Teng, Yong Xu · 发表于：Frontiers in Medicine · 年份：2022 · DOI：10.3389/fmed.2021.759825 · 被引用次数：14 · 研究领域：Bone Metabolism and Diseases、Bone health and osteoporosis research、Bone and Dental Protein Studies

Background: Maresin 1 plays a role in the regulation of inflammation and metabolic diseases in vivo . An increasing number of studies have reported that postmenopausal osteoporosis (PMOP) is associated with inflammation. However, the potential relationship between the serum Maresin 1 content and PMOP is unclear. Aims: 1) To evaluate the Maresin 1 content in postmenopausal women with osteopenia, osteoporosis, or without these conditions (normal group) and 2) to analyze the correlations between Maresin 1 concentrations and bone mineral density (BMD) and bone turnover markers. Methods: In this cross-sectional study, we measured serum Maresin 1 concentrations, serum biochemical parameters, markers of bone metabolism, and BMD of the femoral neck, lumbar spine, and hip in 141 postmenopausal women. Results: We found that serum Maresin 1 in the osteopenia (140.09 ± 30.54 pg/ml) and PMOP (124.68 ± 31.35 pg/ml) groups were significantly lower than those in the normal group (167.38 ± 24.85 pg/ml) ( P < 0.05 and P < 0.001). Serum Maresin 1 levels were positively correlated with femoral neck, lumbar spine, and hip BMD ( P < 0.001). Meanwhile, Maresin 1 concentrations were positively associated with 25-hydroxyvitamin D [25(OH)D] levels ( P < 0.001), but negatively correlated with β-CrossLaps of type 1 collagen containing cross-linked C-telopeptide (β-CTX) ( P = 0.002), procollagen type I amino-terminal propeptide (PINP) ( P = 0.004), tartrate-resistant acid phos...