Visible-Light-Enabled Allylic C–H Oxidation: Metal-free Photocatalytic Generation of Enones

作者：Chao Liu, Hui Liu, Xuan Zheng, Shanyi Chen, Qihong Lai, Changlong Zheng, Mingqiang Huang, Kaicong Cai, Zhixiong Cai, Shunyou Cai · 发表于：ACS Catalysis · 年份：2022 · DOI：10.1021/acscatal.1c05124 · 被引用次数：61 · 研究领域：Radical Photochemical Reactions、Catalytic C–H Functionalization Methods、Oxidative Organic Chemistry Reactions

A practical and efficient method has been established for the direct oxidation of allylic C–H bonds catalyzed by visible-light-enabled photoredox agents. This protocol uses oxygen as the sole oxidant under metal-free conditions at room temperature and produces functionalized enones. When combined with acid-promoted dehydration, this benign and mild method enables the production of meta-functionalized phenols from simple cyclohexenols. A key to this reaction is the choice of tetrabutylammonium bromide as a hydrogen atom transfer cocatalyst.