AgNTf 2 -Catalyzed Regioselective C–H Alkenylation of N,N -Dialkylanilines with Ynamides

作者：Xiao-Di Nie, Zhuo‐Ya Mao, Jia‐Ming Guo, Chang‐Mei Si, Bang‐Guo Wei, Guo‐Qiang Lin · 发表于：The Journal of Organic Chemistry · 年份：2022 · DOI：10.1021/acs.joc.1c02263 · 被引用次数：13 · 研究领域：Catalytic C–H Functionalization Methods、Catalytic Alkyne Reactions、Cyclopropane Reaction Mechanisms

Regioselective C–H alkenylation of N,N -dialkylanilines with ynamides was developed using AgNTf 2 as a catalyst. This approach represents a facile hydroarylation of ynamides, allowing for the introduction of an alkenyl group exclusively at the para position of aniline derivatives. As a result, a series of 4-alkenyl N,N -dialkylanilines were synthesized with excellent regioselectivities.