Characterization of E-cadherin expression in normal mucosa, dysplasia and adenocarcinoma of gastric cardia and its influence on prognosis

作者：Hai‐Ling Wang, Xueke Zhao, Fuyou Zhou, Xin Song, Liu-Yu Li, Gairong Huang, Qi-De Bao, Ling-Ling Lei, Haijun Yang, Li Li, Rui‐Hua Xu, Aili Li, Xianzeng Wang, Wen-Li Han, Jingli Ren, Lidong Wang · 发表于：World Journal of Gastrointestinal Oncology · 年份：2022 · DOI：10.4251/wjgo.v14.i1.265 · 被引用次数：4 · 研究领域：Wnt/β-catenin signaling in development and cancer、Cancer Cells and Metastasis、Esophageal Cancer Research and Treatment

BACKGROUND: Gastric cardia adenocarcinoma (GCA), which has been classified as type II adenocarcinoma of the esophagogastric junction in western countries, is of similar geographic distribution with esophageal squamous cell carcinoma in China, and even referred as "sister cancer" by Chinese oncologists. The molecular mechanism for GCA is largely unknown. Recent studies have shown that decreased expression of E-cadherin is associated with the invasion and metastasis of multiple cancers. However, the E-cadherin expression has not been well characterized in gastric cardia carcinogenesis and its effect on GCA prognosis. AIM: To characterize E-cadherin expression in normal gastric cardia mucosa, dysplasia and GCA tissues, and its influence on prognosis for GCA. METHODS: = 156) were collected, and processed as tissue microarray for immunohistochemistry. The clinicopathological characteristics were retrieved from the medical records in hospital and follow-up was carried out through letter, telephone or home interview. E-cadherin protein expression was determined by two step immunohistochemistry. Kaplan-Meier and Cox regression analyses were used to correlate E-cadherin protein expression with survival of GCA patients. RESULTS: = 0.011). CONCLUSION: E-cadherin expression may be involved in gastric cardia carcinogenesis and low expression of E-cadherin may be a promising early biomarker and overall survival predictor for GCA.