Molecular recognition-driven supramolecular nanoassembly of a hydrophobic uracil prodrug and hydrophilic cytarabine for precise combination treatment of solid and non-solid tumors

作者：Chang Li, Qiu Wang, Dan Li, Yubo Liu, Baichun Hu, Yao Feng, Haotian Zhang, Zhonggui He, Cong Luo, Jin Sun · 发表于：Nanoscale Horizons · 年份：2022 · DOI：10.1039/d1nh00590a · 被引用次数：11 · 研究领域：Advanced biosensing and bioanalysis techniques、Nanoplatforms for cancer theranostics、RNA Interference and Gene Delivery

The reduction sensitive supramolecular nanoassembly was based on U-SS-DOX and Ara-C specific molecular recognition. The drug release in the supramolecular nanoassembly was triggered and controlled in tumor cells with low pH and excessive GSH.