SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses

作者：Wanwisa Dejnirattisai, Jiandong Huo, Daming Zhou, Jiří Zahradník, Piyada Supasa, Chang Liu, Helen M. E. Duyvesteyn, Helen Mary Ginn, Alexander J. Mentzer, Aekkachai Tuekprakhon, Rungtiwa Nutalai, Beibei Wang, Aiste Dijokaite-Guraliuc, Suman Khan, Ori Avinoam, Mohammad W. Bahar, Donal Skelly, Sandra Adele, Síle A. Johnson, Ali Amini, Thomas G. Ritter, Chris JB Mason, Christina Dold, Daniel Pan, Sara Assadi, Adam Bellass, Nicola Omo-Dare, David Koeckerling, Amy Flaxman, Daniel Jenkin, Parvinder K. Aley, Merryn Voysey, Sue Ann Costa Clemens, Felipe Gomes Naveca, Valdinete Alves do Nascimento, Fernanda Nascimento, Cristiano Fernandes da Costa, Paola Cristina Resende, Alex Pauvolid‐Corrêa, Marilda Mendonça Siqueira, Vicky Lynne Baillie, Natali Serafin, Gaurav Kwatra, Kelly da Silva, Shabir Ahmed Madhi, Marta Coelho Nunes, Tariq Malik, Peter Openshaw, John Kenneth Baillie, Malcolm Gracie Semple, Alain Townsend, Kuan-Ying Arthur Huang, Tiong Kit Tan, Miles W. Carroll, Paul Klenerman, Eleanor Barnes, Susanna Jane Dunachie, Bede Constantinides, Hermione J. Webster, Derrick W. Crook, Andrew John Pollard, Teresa Lambe, Christopher P. Conlon, Alexandra S. Deeks, John Frater, Lisa Frending, Siobhan Gardiner, Anni Jämsén, Katie JM Jeffery, Tom Malone, Eloise Phillips, Lucy Rothwell, Lizzie Stafford, John Kenneth Baillie, Malcolm Gracie Semple, Peter Openshaw, Gail Carson, Beatrice Alex, Petros Andrikopoulos, Benjamin Bach, William Barclay, Debby Bogaert, Meera A Chand, Kanta Chechi, Graham S. Cooke, Ana da Silva Filipe, Thushan I. de Silva, Annemarie Beth Docherty, Gonçalo dos Santos Correia, Marc‐Emmanuel Dumas, Jake W Dunning, Tom E. Fletcher, Chris A Green, William Greenhalf, Julian Leether Griffin, Rishi K Gupta, Ewen Munro Harrison, Julian A. Hiscox, Antonia Ying Wai Ho, Peter Horby, Samreen Ijaz, Saye Khoo, Paul Klenerman, Andrew Law, Matthew R. Lewis, Sonia Liggi, Wei Shen Lim, Lynn Maslen, Alexander J. Mentzer, Laura Merson, Alison M Meynert, Shona C. Moore, Mahdad Noursadeghi, Michael T. Olanipekun, Anthonia Osagie, Massimo Palmarini, Carlo Palmieri, William A. Paxton, Georgios Pollakis, Nicholas Price, Andrew Rambaut, David L. Robertson, Clark D Russell, Vanessa Sancho‐Shimizu, Caroline J. Sands, Janet T. Scott, Louise Sigfrid, Tom Solomon, Shiranee Sriskandan, David Ian Stuart, David Stuart, Charlotte Summers, Olivia V. Swann, Zoltán Takáts, Panteleimon G. Takis, Richard S. Tedder, AA Roger Thompson, Emma C. Thomson, Ryan S. Thwaites, Lance C. W. Turtle, Maria Cristina Fleischmann Alves Zambon, Hayley Hardwick, Chloe Donohue, Fiona Griffiths, Wilna Oosthuyzen, Cara Donegan, Rebecca G. Spencer, Lisa Norman, Riinu Pius, Thomas M. Drake, Cameron J Fairfield, Stephen Richard Knight, Kenneth A McLean, Derek B. Murphy, Catherine A. Shaw, Jo Dalton, Michelle Girvan, Egle Saviciute, Stephanie Roberts, Janet Harrison, Laura Clare Marsh, Marie Connor, Sophie Halpin, Clare Jackson, Carrol L. Gamble, Daniel Plotkin, James D. Lee, Gary Leeming, Andrew Law, Murray Wham, Sara Clohisey, Ross Hendry, James Scott-Brown, Victoria Shaw, Sarah E. McDonald, Seán Keating, Katie A. Ahmed, Jane A. Armstrong, Milton Ashworth, Innocent Gerald Asiimwe, Siddharth Bakshi, Samantha L Barlow, Laura Booth, Benjamin Brennan, Katie Bullock, Benjamin WA Catterall, Jordan J. Clark, Emily A Clarke, Sarah Cole, Louise M. Cooper, Helen Suzanne Cox, Christopher Davis, Oslem Dincarslan, Chris Dunn, PHILIP A. DYER, Angela Elliott, Anthony Evans, Lorna S Finch, Lewis WS Fisher, Terry Foster, Isabel García-Dorival, Philip Gunning, Catherine S. Hartley, Rebecca L. Jensen, Christopher B. Jones, Trevor R. Jones, Shadia Khandaker, Katharine Alice King, Robyn T. Kiy, Chrysa Koukorava, Annette Lake, Suzannah B. Lant, Diane Latawiec, Lara Lavelle-Langham, Daniella A. Lefteri, Lauren Lett, Lucia A Livoti, Maria Vittoria Mancini, Sarah McDonald, Laurence McEvoy, John McLauchlan, Soeren Metelmann, Nahida S Miah, Joanna Middleton, Joyce Mitchell, Shona C. Moore, E. Gordon Murphy, Rebekah Penrice-Randal, Jack Pilgrim, Tessa Prince, Will Reynolds, Paul Ridley, Debby Sales, Victoria E. Shaw, Rebecca K. Shears, Benjamin Small, Krishanthi S. Subramaniam, Agnieska Szemiel, Aislynn Taggart, Jolanta Tanianis-Hughes, Jordan Thomas, Erwan Trochu, Libby v. Tonder, Eve Wilcock, Jinyan Zhang, Lisa Flaherty, Nicole Maziere, Emily Cass, Alejandra Doce Carracedo, Nicola Carlucci, Anthony M Holmes, Hannah Massey, Lee D. Murphy, Sarah McCafferty, Richard C. Clark, Angie Fawkes, Kirstie Morrice, Alan W Maclean, Nicola Wrobel, Lorna Donnelly, Audrey Coutts, Katarzyna Hafezi, Louise MacGillivray, Tammy Gilchrist, Kayode Adebamiji Adeniji, Daniel D. Agranoff, Ken Agwuh, Dhiraj Ail, Erin L. Aldera, Ana Alegria, Sam Allen, Brian Angus, Abdul Ashish, Dougal Atkinson, Shahedal Bari, Gavin D Barlow, Stella Barnass, Nicholas A. Barrett, Christopher Bassford, Sneha Basude, David G. Baxter, Michael B. J. Beadsworth, Jolanta Bernatoniene, John C. Berridge, Colin Berry, Nicola G. Best, Pieter Bothma, David Chadwick, Robin Brittain-Long, Naomi Bulteel, Tom Burden, Andrew J. Burtenshaw, Vikki Caruth, David Chadwick, Duncan Chambler, Nigel Chee, Jenny Child, Srikanth Chukkambotla, Tom Clark, Paul Collini, Catherine Cosgrove, Jason Cupitt, Maria-Teresa Cutino-Moguel, Paul M Dark, Chris Dawson, Samir Dervisevic, Phil Donnison, Sam T Douthwaite, Andrew Drummond, Ingrid DuRand, Ahilanadan Dushianthan, Tristan Dyer, Cariad M. Evans, Chi Eziefula, Chrisopher Fegan, Adam H.R. Finn, Duncan Fullerton, Sanjeev Garg, Atul Garg, Atul Garg, Effrossyni Gkrania‐Klotsas, Jo Godden, Arthur R. Goldsmith, Clive Graham, Elaine Hardy, Stuart Hartshorn, D.J. Harvey, Peter Havalda, Daniel B. Hawcutt, Maria Hobrok, Luke Eliot Hodgson, Anil P. Hormis, Michael E. Jacobs, Susan Jain, Paul B. Jennings, Agilan Kaliappan, Vidya Kasipandian, Stephen Kegg, Michael C. Kelsey, Jason Kendall, Caroline Kerrison, Ian Kerslake, Oliver Owen Koch, Gouri Koduri, George Koshy, Shondipon Laha, Steven Laird, Susan Larkin, Tamás Leiner, Patrick J. Lillie, James Limb, Vanessa Linnett, Jeff Little, Mark David Lyttle, Michael MacMahon, Emily MacNaughton, Ravish Mankregod, Huw Masson, Elijah Matovu, Katherine McCullough, Ruth McEwen, Manjula Meda, GARY H. MILLS, Jane Minton, Mariyam Mirfenderesky, Kavya Mohandas, Quen Mok, James Moon, Elinoor Moore, Patrick W. Morgan, Craig C. Morris, Katherine Mortimore, Samuel E Moses, Mbiye Mpenge, Rohinton Mulla, Michael J. Murphy, Megan Nagel, Thapas Nagarajan, Mark E. Nelson, Lillian Norris, Matthew K. O’Shea, Igor Otahal, Marlies Ostermann, Mark Pais, Carlo Palmieri, Selva Panchatsharam, Danai Papakonstantinou, Hassan Paraiso, Brij Patel, Natalie Pattison, Justin Pepperell, Mark John Peters, Mandeep Phull, Stefania Pintus, Jagtur Singh Pooni, Tim Planche, Frank A. Post, David Anthony Price, Rachel Prout, Nikolas Rae, Henrik Reschreiter, Tim Reynolds, Neil E. Richardson, Mark T. M. Roberts, Devender Roberts, Alistair Rose, Guy G. Rousseau, Bobby Ruge, Brendan Ryan, Taranprit Saluja, Matthias Ludwig Schmid, Aarti Shah, Prad Shanmuga, Anil Kumar Sharma, Anna Shawcross, Jeremy Sizer, Manu Shankar‐Hari, Richard Smith, Catherine M. Snelson, Nick Spittle, Nikki Staines, Tom Stambach, Richard A. Stewart, Pradeep Subudhi, Tamás Szakmány, Kate Colette Tatham, Jo Thomas, Chris Thompson, Robert Thompson, Ascanio Tridente, Darell Tupper-Carey, Mary Twagira, Nick Vallotton, Rama Vancheeswaran, Lisa Vincent-Smith, Shico Visuvanathan, Alan Vuylsteke, Sam Waddy, Rachel M. Wake, Andrew Walden, Ingeborg Dorothea Welters, Tony Whitehouse, Paul A. Whittaker, Ashley Whittington, Padmasayee Papineni, Meme Wijesinghe, Martin A. K. Williams, Lawrence Wilson, Sarah Cole, Stephen Winchester, Martin J Wiselka, Adam Wolverson, Dan Wootton, Andrew Workman, Bryan Yates, P. A. Young, Neil G. Paterson, Mark A. Williams, David R. Hall, Elizabeth E. Fry, Juthathip Mongkolsapaya, Jingshan Ren, Gideon Schreiber, David I. Stuart, David Ian Stuart, Gavin Robert Screaton · 发表于：Cell · 年份：2022 · DOI：10.1016/j.cell.2021.12.046 · 被引用次数：1027 · 研究领域：SARS-CoV-2 and COVID-19 Research、Bacillus and Francisella bacterial research、COVID-19 Clinical Research Studies

November 2021, the sequence of a new SARS-CoV-2 viral isolate Omicron-B.1.1.529 was announced, containing far more mutations in Spike (S) than previously reported variants. Neutralization titers of Omicron by sera from vaccinees and convalescent subjects infected with early pandemic Alpha, Beta, Gamma, or Delta are substantially reduced, or the sera failed to neutralize. Titers against Omicron are boosted by third vaccine doses and are high in both vaccinated individuals and those infected by Delta. Mutations in Omicron knock out or substantially reduce neutralization by most of the large panel of potent monoclonal antibodies and antibodies under commercial development. Omicron S has structural changes from earlier viruses and uses mutations that confer tight binding to ACE2 to unleash evolution driven by immune escape. This leads to a large number of mutations in the ACE2 binding site and rebalances receptor affinity to that of earlier pandemic viruses.