Potential Defects and Improvements of Equivalent Uniform Dose Prediction Model Based on the Analysis of Radiation-Induced Brain Injury

作者：Qinghua Du, Jian Li, Yi-Xiu Gan, Huijun Zhu, Hai-Ying Yue, Xiangde Li, Xue Ou, Qiulu Zhong, Danjing Luo, Yiting Xie, Qian-fu Liang, Rensheng Wang, Wenqi Liu · 发表于：Frontiers in Oncology · 年份：2022 · DOI：10.3389/fonc.2021.743941 · 被引用次数：1 · 研究领域：Advanced Radiotherapy Techniques、Radiation Therapy and Dosimetry、Radiation Dose and Imaging

Purpose To study the impact of dose distribution on volume-effect parameter and predictive ability of equivalent uniform dose (EUD) model, and to explore the improvements. Methods and Materials The brains of 103 nasopharyngeal carcinoma patients treated with IMRT were segmented according to dose distribution (brain and left/right half-brain for similar distributions but different sizes; V D with different D for different distributions). Predictive ability of EUD V D (EUD of V D ) for radiation-induced brain injury was assessed by receiver operating characteristics curve (ROC) and area under the curve (AUC). The optimal volume-effect parameter a of EUD was selected when AUC was maximal (mAUC). Correlations between mAUC, a and D were analyzed by Pearson correlation analysis. Both mAUC and a in brain and half-brain were compared by using paired samples t -tests. The optimal D V and V D points were selected for a simple comparison. Results The mAUC of brain/half-brain EUD was 0.819/0.821 and the optimal a value was 21.5/22. When D increased, mAUC of EUD V D increased, while a decreased. The mAUC reached the maximum value when D was 50–55 Gy, and a was always 1 when D ≥55 Gy. The difference of mAUC/ a between brain and half-brain was not significant. If a was in range of 1 to 22, AUC of brain/half-brain EUD V55 Gy (0.857–0.830/0.845–0.830) was always larger than that of brain/half-brain EUD (0.681–0.819/0.691–0.821). The AUCs of optimal dose/volume points were 0.801 (brain D 2.5 c...