Langerhans cell histiocytosis presenting as an isolated brain tumour: A case report

作者：Han-Xiang Liang, Yue-Long Yang, Qing Zhang, Zhi Xie, Entao Liu, Shuxia Wang · 发表于：World Journal of Clinical Cases · 年份：2022 · DOI：10.12998/wjcc.v10.i4.1423 · 被引用次数：4 · 研究领域：Histiocytic Disorders and Treatments、Tuberous Sclerosis Complex Research、Cardiac tumors and thrombi

BACKGROUND: Langerhans cell histiocytosis (LCH) is a rare proliferative histiocyte disorder. It can affect any organ or system, especially the bone, skin, lung, and central nervous system (CNS). In the CNS, the hypothalamic-pituitary is predominantly affected, whereas the brain parenchyma is rarely affected. LCH occurring in the brain parenchyma can be easily confused with glioblastoma or brain metastases. Thus, multimodal imaging is useful for the differential diagnosis of these intracerebral lesions and detection of lesions in the other organs. CASE SUMMARY: F-FDG uptake and multiple cysts in the upper lobes of both lungs were noted, which was also confirmed by high-resolution CT. Thus, the patient underwent surgical resection of the brain lesion for further examination. Postoperative pathology confirmed LCH. The patient received chemotherapy after surgery. No recurrence was observed in the brain at the 12-mo follow-up. CONCLUSION: Multimodal imaging is useful for evaluating the systemic condition of LCH, developing treatment plans, and designing post-treatment strategies.