Stem Cell Transplantation and Cell-Free Treatment for Periodontal Regeneration

作者：Kengo Iwasaki, Yihao Peng, Ryuhei Kanda, Makoto Umeda, Isao Ishikawa · 发表于：International Journal of Molecular Sciences · 年份：2022 · DOI：10.3390/ijms23031011 · 被引用次数：44 · 研究领域：Periodontal Regeneration and Treatments、Mesenchymal stem cell research、Oral microbiology and periodontitis research

Increasing attention has been paid to cell-based medicines. Many in vivo and in vitro studies have demonstrated the efficacy of stem cell transplantation for the regeneration of periodontal tissues over the past 20 years. Although positive evidence has accumulated regarding periodontal regeneration using stem cells, the exact mechanism of tissue regeneration is still largely unknown. This review outlines the practicality and emerging problems of stem cell transplantation therapy for periodontal regeneration. In addition, possible solutions to these problems and cell-free treatment are discussed.