Qualitative and Quantitative Assessment of Emphysema Using Dark-Field Chest Radiography

作者：Theresa Urban, Florian T. Gassert, Manuela Frank, Konstantin Willer, Wolfgang Noichl, Philipp Buchberger, Rafael Schick, Thomas Koehler, Jannis Bodden, Alexander A. Fingerle, Andreas Sauter, Marcus R. Makowski, Franz Pfeiffer, Daniela Pfeiffer · 发表于：Radiology · 年份：2022 · DOI：10.1148/radiol.212025 · 被引用次数：59 · 研究领域：Advanced X-ray Imaging Techniques、Medical Imaging Techniques and Applications、Advanced X-ray and CT Imaging

Background Dark-field chest radiography allows for assessment of lung alveolar structure by exploiting wave optical properties of x-rays. Purpose To evaluate the qualitative and quantitative features of dark-field chest radiography in participants with pulmonary emphysema as compared with those in healthy control subjects. Materials and Methods In this prospective study conducted from October 2018 to October 2020, participants aged at least 18 years who underwent clinically indicated chest CT were screened for participation. Inclusion criteria were an ability to consent to the procedure and stand upright without help. Exclusion criteria were pregnancy, serious medical conditions, and any lung condition besides emphysema that was visible on CT images. Participants were examined with a clinical dark-field chest radiography prototype that simultaneously acquired both attenuation-based radiographs and dark-field chest radiographs. Dark-field coefficients were tested for correlation with each participant’s CT-based emphysema index using the Spearman correlation test. Dark-field coefficients of adjacent groups in the semiquantitative Fleischner Society emphysema grading system were compared using a Wilcoxon Mann-Whitney U test. The capability of the dark-field coefficient to enable detection of emphysema was evaluated with receiver operating characteristics curve analysis. Results A total of 83 participants (mean age, 65 years ± 12 [standard deviation]; 52 men) were studied. When c...