Imipramine and social-vocational adjustment in chronic depression

作者：James H. Kocsis, A J Frances, Carlyle B. Voss, Brooke Mason, Joseph John Mann, John A. Sweeney · 发表于：American Journal of Psychiatry · 年份：1988 · DOI：10.1176/ajp.145.8.997 · 被引用次数：75 · 研究领域：Treatment of Major Depression、Child and Adolescent Psychosocial and Emotional Development、Mental Health Research Topics

The authors compared the effects of 6 weeks of imipramine treatment with 6 weeks of placebo treatment on social and vocational impairment in chronic depression. Imipramine was associated with significantly greater pre- to posttreatment improvement of social-vocational impairments in chronic depression, suggesting that these impairments may have represented affective symptoms rather than characterologic deficits.