Rheumatoid Arthritis: Pathogenic Roles of Diverse Immune Cells

作者：Sun‐Hee Jang, Eui-Jong Kwon, Jennifer Lee · 发表于：International Journal of Molecular Sciences · 年份：2022 · DOI：10.3390/ijms23020905 · 被引用次数：577 · 研究领域：Rheumatoid Arthritis Research and Therapies、Systemic Lupus Erythematosus Research、Chronic Lymphocytic Leukemia Research

Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease associated with synovial tissue proliferation, pannus formation, cartilage destruction, and systemic complications. Currently, advanced understandings of the pathologic mechanisms of autoreactive CD4+ T cells, B cells, macrophages, inflammatory cytokines, chemokines, and autoantibodies that cause RA have been achieved, despite the fact that much remains to be elucidated. This review provides an updated pathogenesis of RA which will unveil novel therapeutic targets.