The effects of the interaction between BMI and dyslipidemia on hypertension in adults

作者：Na Tang, Jian Ma, Rongqin Tao, Zhijun Chen, Yide Yang, Quanyuan He, Yuan Lv, Zelong Lan, Junhua Zhou · 发表于：Scientific Reports · 年份：2022 · DOI：10.1038/s41598-022-04968-8 · 被引用次数：109 · 研究领域：Nutritional Studies and Diet、Cardiovascular Disease and Adiposity、Blood Pressure and Hypertension Studies

Abstract Body mass index (BMI) and dyslipidemia are indicators of human health and are often associated with high blood pressure. In this study,we explored the relationship between BMI or dyslipidemia and the risk of hypertension and further verified the possible interacting influences of BMI with dyslipidemia on the risk of hypertension. The aim is to explore the possible risk factors of hypertension and to provide scientific basis for the prevention and treatment of hypertension. Eligible subjects were selected from a cross-sectional survey in Changsha City, and we collected relevant data and clinical indicators for each participant. Body mass index (BMI) was calculated as weight (kg)/height 2 (m 2 ), and divided into four categories according to the Chinese standard. Dyslipidemia is defined according to Chinese guideline. Unconditional logistic regression models were used for dichotomous variables to determine the risk or protective factors of dependent variables. Multivariate Logistic model was used to study the influence of BMI and dyslipidemia on hypertension. The following indicators were used to assess the interaction effects: (1) Relative excess risk due to interaction (RERI); (2) Attributable proportion due to interaction(AP); (3) Synergy index (SI). SPSS software was used for statistical analysis. A total of 2740 eligible participants were enrolled in the cross-sectional study, of which 765 subjects (27.9%) were diagnosed with hypertension. Multivariate Logistic mo...